TB-500 — Synthetic Thymosin Beta-4 Fragment Research Compound

Catalog ID: TB50 | CAS: 77591-33-4 | Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Lys | Formula: C₂₁₂H₃₅₀N₅₆O₇₈S

Compound Overview

TB-500 is a synthetic version of a short peptide segment derived from Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid protein.
It is utilized in in vitro and in vivo studies to investigate cell migration, angiogenic signaling, and actin cytoskeleton regulation in mammalian systems.
For laboratory research use only — not for human consumption or therapeutic application.

Molecular Characteristics

• Synonyms: Thymosin Beta-4 fragment; TB500
• CAS Number: 77591-33-4
• Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Lys
• Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
• Molecular Weight: ≈ 4963.5 g/mol
• Purity: ≥ 98% (HPLC verified)
• Formulation: Lyophilized peptide powder

Physical Properties

• Appearance: White to off-white lyophilized powder
• Solubility: Sterile water or 0.6% acetic acid (for research use only)
• Container: Sterile sealed vial

Storage & Stability

• Unreconstituted: Store at −20 °C, protected from light and moisture.
• Reconstituted: Aliquot and store at −20 °C; avoid repeated freeze–thaw cycles.

Research Context

TB-500 is used in experimental models to examine **cytoskeletal organization, peptide-driven cell motility, and angiogenic responses**.
Studies focus on its ability to modulate **actin polymerization**, **fibroblast migration**, and **cellular repair signaling pathways**.
It is often studied alongside **BPC-157** and **GHK-Cu** in research investigating **tissue modeling, vascular peptide communication, and cellular structural regulation**.