SNAP-8 (Acetyl Octapeptide-3) — Neurotransmission Modulating Peptide Research Compound

Catalog ID: SNAP | CAS: 868844-74-0 | Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂

Compound Overview

SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide derived from the N-terminal domain of SNAP-25, a substrate of the synaptosomal-associated protein family.
It is studied in research models for its ability to modulate **SNARE complex formation**, **vesicle docking**, and **synaptic neurotransmission processes**.
For laboratory research use only — not for human consumption or cosmetic/therapeutic application.

Molecular Characteristics

• Synonyms: Acetyl Octapeptide-3; SNAP25 fragment peptide
• CAS Number: 868844-74-0
• Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂
• Molecular Formula: C₃₉H₆₀N₁₄O₁₂S
• Molecular Weight: ≈ 1075.1 g/mol
• Purity: ≥ 98% (HPLC verified)
• Formulation: Lyophilized peptide powder

Physical Properties

• Appearance: White to off-white lyophilized powder
• Solubility: Sterile water, DMSO, or PBS (for research use only)
• Container: Sterile sealed vial

Storage & Stability

• Unreconstituted: Store at −20 °C, protected from light and moisture.
• Reconstituted: Aliquot and store at −20 °C; avoid repeated freeze–thaw cycles.

Research Context

SNAP-8 is utilized in in vitro and biochemical research focused on **synaptic vesicle fusion**, **neurotransmitter exocytosis**, and **SNARE complex protein interactions**.
As a short-chain analog of SNAP-25, it provides a model system for understanding **protein–protein binding inhibition**, **membrane fusion dynamics**, and **neuropeptide structure–function relationships**.
Research highlights include studies into **neural communication pathways, vesicle trafficking, and peptide-mimetic receptor regulation** in cellular systems.