HCG (Human Chorionic Gonadotropin) — Glycoprotein Hormone Analog Research Compound

Catalog ID: HCG | CAS: 9002-61-3 | Structure: Glycoprotein composed of α (92 amino acids) and β (145 amino acids) subunits

Compound Overview

HCG (Human Chorionic Gonadotropin) is a recombinant glycoprotein hormone analog composed of α and β subunits linked by non-covalent interactions.
It shares significant sequence homology with **Luteinizing Hormone (LH)** and is used in research investigating **gonadotropin receptor activation**, **signal transduction**, and **cellular endocrine regulation**.
For laboratory research use only — not for human consumption or therapeutic application.

Molecular Characteristics

• Synonyms: Chorionic Gonadotropin; Human CG; Glycoprotein Hormone Analog
• CAS Number: 9002-61-3
• Composition: Two non-covalently linked subunits — α (92 AA) and β (145 AA)
• Molecular Formula: Approx. C₁₁₀₀H₁₇₇₈N₃₁₄O₃₃₆S₂₆
• Molecular Weight: ≈ 36.7 kDa
• Purity: ≥ 98% (HPLC verified)
• Formulation: Lyophilized recombinant glycoprotein

Physical Properties

• Appearance: White to off-white lyophilized powder
• Solubility: Sterile water or isotonic buffer (for research use only)
• Container: Sterile sealed vial

Storage & Stability

• Unreconstituted: Store at −20 °C, protected from light and moisture.
• Reconstituted: Aliquot and store at −20 °C; avoid repeated freeze–thaw cycles.

Research Context

HCG is studied in controlled in vitro and in vivo models examining **gonadotropin receptor (LHCGR) activation**, **cAMP-mediated signaling**, and **steroidogenic pathway regulation**.
Research focuses include **pituitary–gonadal communication**, **glycoprotein hormone receptor dynamics**, and **β-subunit specificity in endocrine signaling**.
It is often compared with **LH, FSH, and Kisspeptin peptides** in studies mapping **hormonal feedback and receptor cross-activity**.