PT-141 (Bremelanotide) — Melanocortin Receptor Peptide Analog Research Compound

Catalog ID: PT14 | CAS: 189691-06-3 | Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH

Compound Overview

PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide analog of α-MSH (alpha-melanocyte-stimulating hormone), part of the **melanocortin peptide family**.
It is studied in controlled laboratory environments for its role in **melanocortin receptor binding, GPCR activation, and central peptide signaling pathways**.
For laboratory research use only — not for human consumption or therapeutic application.

Molecular Characteristics

• Synonyms: Bremelanotide; PT141; α-MSH analog
• CAS Number: 189691-06-3
• Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH
• Molecular Formula: C₅₀H₆₈N₁₄O₁₀
• Molecular Weight: ≈ 1025.2 g/mol
• Purity: ≥ 98% (HPLC verified)
• Formulation: Lyophilized peptide powder

Physical Properties

• Appearance: White to off-white lyophilized powder
• Solubility: Sterile water or 0.6% acetic acid (for research use only)
• Container: Sterile sealed vial

Storage & Stability

• Unreconstituted: Store at −20 °C, protected from light and moisture.
• Reconstituted: Aliquot and store at −20 °C; avoid repeated freeze–thaw cycles.

Research Context

PT-141 is used in in vitro and in vivo research models examining **melanocortin receptor function (MC1R–MC5R)** and **neuropeptide signaling pathways**.
It serves as a **reference analog** for studying the effects of cyclic peptides on **G-protein coupled receptor (GPCR) binding**, **receptor affinity**, and **intracellular cAMP activation**.
Ongoing studies investigate PT-141’s molecular role in **melanocortin system signaling and central neuropeptide regulation** within experimental frameworks.