MOTS-c — Mitochondrial-Derived Peptide Research Compound

Catalog ID: MOTS | CAS: 1446243-19-9 | Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Compound Overview

MOTS-c is a synthetic mitochondrial-encoded peptide composed of 16 amino acids.
It is provided in high-purity, research-grade form for studies exploring mitochondrial communication, metabolic adaptation, and cellular stress-response pathways.
Not for human consumption or therapeutic application.

Molecular Characteristics

• Synonyms: Mitochondrial Open Reading Frame of the 12S rRNA-c peptide
• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• Molecular Formula: C₂₀₆H₃₁₇N₅₇O₄₆S₁
• Molecular Weight: ≈ 2173.4 g/mol
• Purity: ≥ 98% (HPLC)
• Formulation: Lyophilized peptide powder

Physical Properties

• Appearance: White to off-white lyophilized powder
• Solubility: Sterile water or 0.6 % acetic acid (for research use only)
• Container: Sterile sealed vial

Storage & Stability

• Unreconstituted: Store at −20 °C, protected from light and moisture.
• Reconstituted: Aliquot and store at −20 °C; avoid repeated freeze–thaw cycles.

Research Context

MOTS-c has been studied in in vitro and in vivo model systems for its influence on AMP-activated protein kinase (AMPK) signaling, mitochondrial biogenesis, and cellular stress adaptation.
Research applications focus on its potential role as a mitochondrial signaling peptide involved in metabolic homeostasis, energy sensing, and inter-organelle communication.