Sermorelin (GRF 1–29) — Growth Hormone Releasing Factor Analog Research Compound

Catalog ID: SERM | CAS: 86168-78-7 | Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂

Compound Overview

Sermorelin, also known as GRF 1–29, is a synthetic peptide analog of growth hormone-releasing hormone (GHRH) containing the biologically active fragment of the native 44-amino-acid hormone.
It is studied in in vitro and in vivo models for its role in pituitary somatotroph activation, cyclic AMP (cAMP) signaling, and peptide-mediated endocrine regulation.
For laboratory research use only — not for human consumption or therapeutic application.

Molecular Characteristics

• Synonyms: GRF 1–29; Sermorelin Acetate; Growth Hormone Releasing Factor (1–29) NH₂
• CAS Number: 86168-78-7
• Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
• Molecular Formula: C₁₄₉H₂₄₆N₄₄O₄₂S
• Molecular Weight: ≈ 3357.9 g/mol
• Purity: ≥ 98% (HPLC verified)
• Formulation: Lyophilized peptide powder

Physical Properties

• Appearance: White to off-white lyophilized powder
• Solubility: Sterile water or 0.6% acetic acid (for research use only)
• Container: Sterile sealed vial

Storage & Stability

• Unreconstituted: Store at −20 °C, protected from light and moisture.
• Reconstituted: Aliquot and store at −20 °C; avoid repeated freeze–thaw cycles.

Research Context

Sermorelin is utilized in experimental research studying **growth hormone regulation, hypothalamic–pituitary feedback loops, and peptide-based neuroendocrine signaling**.
It serves as a **reference molecule** for analyzing the effects of truncated GHRH sequences on receptor activation and downstream **signal transduction pathways**.
Studies focus on its interaction with **GHRH receptors (GHRHR)** and its potential influence on **growth hormone synthesis and release mechanisms** in controlled research models.