CJC-1295 (Without DAC) — GH Releasing Hormone Analog Research Compound

Catalog ID: CJCN | CAS: 863288-34-0 | Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂

Compound Overview

CJC-1295 (Without DAC) is a synthetic GHRH analog engineered to mimic the endogenous peptide responsible for stimulating growth hormone release from pituitary somatotroph cells.
The “Without DAC” variant lacks the Drug Affinity Complex (DAC) modification, allowing for **shorter-acting pharmacokinetic modeling** and **precise receptor binding studies** in controlled environments.
For laboratory research only — not for human consumption or therapeutic application.

Molecular Characteristics

• Synonyms: GHRH (1-29) analog; Modified growth hormone releasing factor
• CAS Number: 863288-34-0
• Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
• Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
• Molecular Weight: ≈ 3357.9 g/mol
• Purity: ≥ 98% (HPLC verified)
• Formulation: Lyophilized peptide powder

Physical Properties

• Appearance: White to off-white lyophilized powder
• Solubility: Sterile water or 0.6% acetic acid (for research use only)
• Container: Sterile sealed vial

Storage & Stability

• Unreconstituted: Store at −20 °C, protected from light and moisture.
• Reconstituted: Aliquot and store at −20 °C; avoid repeated freeze–thaw cycles.

Research Context

CJC-1295 (Without DAC) is employed in preclinical studies examining pituitary GHRH receptor activation, cAMP signaling, and somatotropic gene expression.
Researchers utilize this analog to study pulsatile GH secretion patterns and feedback control mechanisms within the endocrine system.
Comparative research between the DAC and non-DAC variants enables investigation of **peptide half-life modulation and receptor occupancy kinetics**.