Gonadorelin — Peptide Research Compound

Catalog ID: GONA | CAS: 33515-09-2 | Sequence: pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂

Compound Overview

Gonadorelin (also known as GnRH) is a synthetic decapeptide identical in sequence to the endogenous hypothalamic hormone responsible for initiating pituitary gonadotropin release.
It is supplied for preclinical research on neuroendocrine signaling, peptide receptor activation, and feedback regulation.
Not for human consumption or therapeutic application.

Molecular Characteristics

• Synonyms: Gonadotropin-Releasing Hormone, LHRH
• Sequence: pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂
• Molecular Formula: C₅₅H₇₅N₁₇O₁₃
• Molecular Weight: ≈ 1182.3 g/mol
• Purity: ≥ 98 % (HPLC)
• Formulation: Lyophilized peptide powder

Physical Properties

• Appearance: White to off-white powder
• Solubility: Sterile water or 0.6 % acetic acid (research use only)
• Container: Sterile sealed vial

Storage & Stability

• Unreconstituted: Store at −20 °C protected from light and moisture.
• Reconstituted: Aliquot and store at −20 °C; avoid repeated freeze–thaw cycles.

Research Context

Gonadorelin serves as a model peptide for pituitary receptor binding, pulsatile secretion mapping, and hypothalamic feedback studies.
It is frequently utilized in in vitro and in vivo systems to investigate GnRH-receptor signal transduction, gonadotropin release kinetics, and peptide analog comparison.