MT-1 (Melanotan I / Afamelanotide) — α-MSH Analog Research Compound

Catalog ID: MT1 | CAS: 75921-69-6 | Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂

Compound Overview

MT-1 (Melanotan I / Afamelanotide) is a synthetic analog of the naturally occurring peptide α-MSH (alpha-melanocyte-stimulating hormone).
It is used in controlled laboratory research for the study of melanocortin receptor pharmacology, signal transduction, and photobiological responses.
For laboratory research use only — not for human consumption or therapeutic/cosmetic application.

Molecular Characteristics

• Synonyms: Afamelanotide; Melanotan I; α-MSH analog
• CAS Number: 75921-69-6
• Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂
• Molecular Formula: C₇₈H₁₁₁N₂₁O₁₉
• Molecular Weight: ≈ 1646.9 g/mol
• Purity: ≥ 98% (HPLC verified)
• Formulation: Lyophilized peptide powder

Physical Properties

• Appearance: White to off-white lyophilized powder
• Solubility: Sterile water or 0.6% acetic acid (for research use only)
• Container: Sterile sealed vial

Storage & Stability

• Unreconstituted: Store at −20 °C, protected from light and moisture.
• Reconstituted: Aliquot and store at −20 °C; avoid repeated freeze–thaw cycles.

Research Context

MT-1 is utilized in in vitro and in vivo experimental systems to explore melanocortin receptor subtype activation, intracellular signaling cascades, and peptide–receptor affinity studies.
Research also investigates its influence on melanogenesis pathways, cyclic AMP (cAMP) signaling, and photoprotective peptide mechanisms.
MT-1 serves as a valuable model compound for studying G-protein coupled receptor (GPCR) peptide dynamics and **melanocortin system regulation**.