Kisspeptin-10 — Neuropeptide Receptor Ligand Research Compound

Catalog ID: KISS | CAS: 32780-32-8 | Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂

Compound Overview

Kisspeptin-10 is a synthetic decapeptide fragment derived from the native 54-amino-acid Kisspeptin protein, a product of the KISS1 gene.
It serves as a selective agonist of the **G-protein coupled receptor GPR54 (also known as KISS1R)**.
Research investigates its role in **neuroendocrine signaling, hypothalamic peptide regulation, and receptor-mediated cellular communication**.
For laboratory research use only — not for human consumption or therapeutic application.

Molecular Characteristics

• Synonyms: KP-10; Metastin fragment; KISS1 decapeptide
• CAS Number: 32780-32-8
• Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
• Molecular Formula: C₆₄H₈₃N₁₇O₁₂
• Molecular Weight: ≈ 1302.5 g/mol
• Purity: ≥ 98% (HPLC verified)
• Formulation: Lyophilized peptide powder

Physical Properties

• Appearance: White to off-white lyophilized powder
• Solubility: Sterile water, acetic acid, or DMSO (for research use only)
• Container: Sterile sealed vial

Storage & Stability

• Unreconstituted: Store at −20 °C, protected from light and moisture.
• Reconstituted: Aliquot and store at −20 °C; avoid repeated freeze–thaw cycles.

Research Context

Kisspeptin-10 is utilized in in vitro and in vivo models studying **peptide–receptor signaling**, **neuroendocrine feedback loops**, and **cellular receptor activation**.
Studies explore its interaction with **GPR54/KISS1R** receptors in relation to **GnRH neuron signaling**, **cellular calcium mobilization**, and **second messenger pathways**.
Comparative research often examines Kisspeptin-10 alongside longer Kisspeptin analogs for understanding **sequence-dependent receptor binding affinity and activity**.