GHRP-2 — Growth Hormone Releasing Hexapeptide Research Compound

Catalog ID: GHR2 | CAS: 158861-67-7 | Sequence: D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂

Compound Overview

GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide designed as a selective agonist of the **growth hormone secretagogue receptor (GHSR-1a)**.
It is widely used in research exploring **pituitary peptide signaling**, **ghrelin receptor dynamics**, and **G-protein coupled receptor (GPCR) activity** related to growth hormone pathways.
For laboratory research use only — not for human consumption or therapeutic application.

Molecular Characteristics

• Synonyms: Growth Hormone Releasing Peptide-2; GHRP2; D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂
• CAS Number: 158861-67-7
• Sequence: D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂
• Molecular Formula: C₄₅H₅₅N₉O₆
• Molecular Weight: ≈ 818.0 g/mol
• Purity: ≥ 98% (HPLC verified)
• Formulation: Lyophilized peptide powder

Physical Properties

• Appearance: White to off-white lyophilized powder
• Solubility: Sterile water or 0.6% acetic acid (for research use only)
• Container: Sterile sealed vial

Storage & Stability

• Unreconstituted: Store at −20 °C, protected from light and moisture.
• Reconstituted: Aliquot and store at −20 °C; avoid repeated freeze–thaw cycles.

Research Context

GHRP-2 is utilized in in vitro and in vivo studies to explore **growth hormone release mechanisms**, **pituitary peptide receptor activation**, and **neuroendocrine signaling cascades**.
Research models compare GHRP-2’s binding affinity and receptor selectivity to related analogs such as **GHRP-6**, **Ipamorelin**, and **Hexarelin**.
Studies emphasize its activity at the **ghrelin/GHSR-1a receptor**, providing valuable insight into **peptide-mediated hormonal communication** in the endocrine system.